The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …

One of the most challenging tasks in the development of protein pharmaceuticals is to deal
with physical and chemical instabilities of proteins. Protein instability is one of the major …

Protein structural flexibility is important for catalysis, binding, and allostery. Flexibility has
been predicted from amino acid sequence with a sliding window averaging technique and …

Comparisons were made among four categories of protein flexibility:(1) low‐B‐factor
ordered regions,(2) high‐B‐factor ordered regions,(3) short disordered regions, and (4) long …

Adeno-associated viruses (AAV) are ubiquitous in the human population (> 90% of adults
are seropositive) but have never been implicated as the cause of any disease. They were …

Formation of β-linked Asp-Xaa peptide bonds–isoaspartyl (isoAsp) sites–arise in proteins
via succinimide− linked deamidation of asparagine or dehydration of aspartate, reactions …

Formation of isoaspartyl peptide bonds (isoAsp) is one of the most common forms of non-
enzymatic degradation of peptides and proteins under mild conditions. IsoAsp arises when …

Reduction of nitrate to ammonium by catalysis using nitrate reductase and nitrite reductase
enzymes characterizes nitrate assimilation. Nitrate assimilation is an important function of …

In the present study, we developed new turn scales based on the occurrence of amino acids
at each of the four positions of a turn using a structural database comprised of 87 proteins …

The accurate determination of a large number of protein structures by X-ray crystallography
makes it possible to conduct a reliable statistical analysis of the distribution of the main …