Recent advances in cancer drug discovery through the use of phenotypic reporter systems, connectivity mapping, and pooled CRISPR screening
N Salame, K Fooks, N El-Hachem… - Frontiers in …, 2022 - frontiersin.org
Multi-omic approaches offer an unprecedented overview of the development, plasticity, and
resistance of cancer. However, the translation from anti-cancer compounds identified in vitro …
resistance of cancer. However, the translation from anti-cancer compounds identified in vitro …
Barbiturate–sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies
AF Kassem, MA Omar, A Temirak… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Design and synthesis of a series of 5-benzylidene (thio) barbiturates 3a–r.
Methodology: Evaluation of the inhibitory activity of the new chemical entities on …
Methodology: Evaluation of the inhibitory activity of the new chemical entities on …
Intratumoral administration of unconjugated Accum™ impairs the growth of pre‐established solid lymphoma tumors
JP Bikorimana, N El‐Hachem, M Moreau… - Cancer …, 2023 - Wiley Online Library
The Accum™ technology was initially designed to enhance the bioaccumulation of a given
molecule in target cells. It does so by triggering endosomal membrane damages allowing …
molecule in target cells. It does so by triggering endosomal membrane damages allowing …
TACIMA-218: a novel pro-oxidant agent exhibiting selective antitumoral activity
J Abusarah, Y Cui, N El-Hachem, AEH El-Kadiry… - Molecular Cancer …, 2021 - AACR
We report the discovery, via a unique high-throughput screening strategy, of a novel
bioactive anticancer compound: T hiol A lkylating C ompound I nducing M assive A poptosis …
bioactive anticancer compound: T hiol A lkylating C ompound I nducing M assive A poptosis …
[图书][B] Engineering a novel cell-based vaccine using immunoproteasome-expressing mesenchymal stromal cells
J Abusarah - 2020 - search.proquest.com
Vaccination remains one of the most successful approaches in preventing and controlling
several infectious diseases. This led to the recent concept of exploiting vaccination in the …
several infectious diseases. This led to the recent concept of exploiting vaccination in the …
[PDF][PDF] The design of sulfur dioxide-releasing linkers for siderophore-based Trojan horse conjugates
CM Black - 2021 - etheses.whiterose.ac.uk
A rise in the number of bacterial strains resistant to both front-line treatment and “last resort”
antibiotics means there is an urgent need for the development of new antimicrobial agents …
antibiotics means there is an urgent need for the development of new antimicrobial agents …