Purification, Characterization, and in Vitro Activity of 2,4-Di-tert-butylphenol from Pseudomonas monteilii PsF84: Conformational and Molecular Docking Studies

S Dharni, Sanchita, A Maurya, A Samad… - Journal of agricultural …, 2014 - ACS Publications
A novel strain of Pseudomonas monteilii, PsF84, was isolated from tannery waste soil from
Jajmau, Kanpur, India. 16S rRNA gene sequence phylogenetic analysis confirmed the …

A label-free continuous fluorescence-based assay for monitoring ornithine decarboxylase activity with a synthetic putrescine receptor

M Nilam, P Gribbon, J Reinshagen… - … Life Sciences R&D, 2017 - journals.sagepub.com
Polyamines play an important role in cell growth, differentiation, and cancer development,
and the biosynthetic pathway of polyamines is established as a drug target for the treatment …

Virtual screening of natural inhibitors targeting ornithine decarboxylase with pharmacophore scaffolding of DFMO and validation by molecular dynamics simulation …

M Sivashanmugam, S KN, UV - Journal of Biomolecular Structure …, 2019 - Taylor & Francis
Ornithine decarboxylase (ODC) is an enzyme that initiates polyamine synthesis in human.
Polyamines play key roles in cell–cell adhesion, cell motility and cell cycle regulation …

In vitro and in silico antifungal efficacy of nitrogen-doped carbon nanohorn (NCNH) against Rhizoctonia solani

S Dharni, Sanchita, SKM Unni, S Kurungot… - Journal of …, 2016 - Taylor & Francis
We have investigated in vitro antifungal efficiency of nitrogen-doped carbon nanohorn
(NCNH) against Rhizoctonia solani (R. solani) plant pathogenic fungi. NCNH with size of 50 …

Biochemical characterization and spatio-temporal analysis of the putative l-DOPA pathway in Mucuna pruriens

SK Singh, SS Dhawan, RK Lal, K Shanker, M Singh - Planta, 2018 - Springer
Main conclusion Transcriptome analysis and biochemical characterization of the putative l-3,
4-dihydroxyphenylalanine (l-DOPA) pathway in Mucuna pruriens (L.) DC have been …

Bioinformatics approaches for structural and functional analysis of proteins in secondary metabolism in Withania somnifera

Sanchita, S Singh, A Sharma - Molecular biology reports, 2014 - Springer
Withania somnifera (Ashwagandha) is an affluent storehouse of large number of
pharmacologically active secondary metabolites known as withanolides. These secondary …

Structural investigations into the binding mode of novel neolignans Cmp10 and Cmp19 microtubule stabilizers by in silico molecular docking, molecular dynamics …

S Tripathi, A Kumar, BS Kumar, AS Negi… - Journal of …, 2016 - Taylor & Francis
Microtubule stabilizers provide an important mode of treatment via mitotic cell arrest of
cancer cells. Recently, we reported two novel neolignans derivatives Cmp 10 and Cmp 19 …

In silico study of binding motifs in squalene synthase enzyme of secondary metabolic pathway solanaceae family

Sanchita, G Singh, A Sharma - Molecular biology reports, 2014 - Springer
Solanaceae is an important family with several plants of medicinal importance. These
medicinal plants have distinctive pathways for secondary metabolite biosynthesis. In most of …

[HTML][HTML] Computational characterization and in vivo expression of squalene synthase gene in different tissues of Artemisia annua L. plants

A Ali, MM Ahmad, MA Khan, AA Ganai, U Kiran… - South African Journal of …, 2016 - Elsevier
Artemisinin, a sesquiterpene lactone endoperoxide isolated from aerial parts of Artemisia
annua L. plants is a safe and potent therapeutic agent against malaria causing drug …

A Quantitative Measure of Conformational Changes in Apo, Holo and Ligand-Bound Forms of Enzymes

S Singh, AK Singh, G Wadhwa, DB Singh… - Interdisciplinary …, 2016 - Springer
Determination of the native geometry of the enzymes and ligand complexes is a key step in
the process of structure-based drug designing. Enzymes and ligands show flexibility in …