The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Voltage-gated ion channels generate electrical signals in species from bacteria to man.
Their voltage-sensing modules are responsible for initiation of action potentials and graded …

The calcium-activated chloride channel TMEM16A is a ligand-gated anion channel that
opens in response to an increase in intracellular Ca2+ concentration,,. The protein is …

Maintenance of a constant cell volume in response to extracellular or intracellular osmotic
changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated …

The heartbeat is initiated by voltage-gated sodium channel Na V 1.5, which opens rapidly
and triggers the cardiac action potential; however, the structural basis for pore opening …

Chili peppers produce the pungent vanilloid compound capsaicin, which offers protection
from predatory mammals. Birds are indifferent to the pain-producing effects of capsaicin and …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-
induced necroptosis. Recent studies on necroptosis execution revealed a commitment role …

Members of the family of B9 vitamins are commonly known as folates. They are derived
entirely from dietary sources and are key one-carbon donors required for de novo nucleotide …