Therapeutic potential of pyrrole and pyrrolidine analogs: an update

N Jeelan Basha, SM Basavarajaiah, K Shyamsunder - Molecular Diversity, 2022 - Springer
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …

Physiological and pharmaceutical considerations for rectal drug formulations

S Hua - Frontiers in pharmacology, 2019 - frontiersin.org
Although the oral route is the most convenient route for drug administration, there are a
number of circumstances where this is not possible from either a clinical or pharmaceutical …

Advancements in rectal drug delivery systems: clinical trials, and patents perspective

R Rathi, Sanshita, A Kumar, V Vishvakarma… - Pharmaceutics, 2022 - mdpi.com
The rectal route is an effective route for the local and systemic delivery of active
pharmaceutical ingredients. The environment of the rectum is relatively constant with low …

Catalyst- and Oxidizing Reagent-Free Electrochemical Benzylic C(sp3)–H Oxidation of Phenol Derivatives

ZW Hou, MM Zhang, WC Yang… - The Journal of Organic …, 2022 - ACS Publications
A site-selective electrochemical approach for the benzylic C (sp3)–H oxidation reaction of
phenol derivatives along with hydrogen evolution has been developed. The protocol …

Achievements in thermosensitive gelling systems for rectal administration

M Bialik, M Kuras, M Sobczak, E Oledzka - International Journal of …, 2021 - mdpi.com
Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route
allows for both local and systemic drug therapy. Traditional rectal dosage formulations have …

Thermoresponsive mucoadhesive hybrid gels in advanced drug delivery systems

K Mfoafo, Y Omidi, H Omidian - International Journal of Pharmaceutics, 2023 - Elsevier
Thermoresponsive polymers have seen extensive use in the development of stimuli-
responsive drug formulations for oral, buccal, nasal, ocular, topical, rectal, parenteral, and …

Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic

JKW Lam, CCK Cheung, MYT Chow, E Harrop… - Advanced Drug Delivery …, 2020 - Elsevier
Abstract The Coronavirus disease 2019 (COVID-19) pandemic has led to a surge in need for
alternative routes of administration of drugs for end of life and palliative care, particularly in …

[HTML][HTML] pH-sensitive in situ gel of mirtazapine Invasomes for rectal drug delivery: Protruded bioavailability and anti-depressant efficacy

EM Eissa, AM El Sisi, MA Bekhet, FIA El-Ela… - Pharmaceuticals, 2024 - mdpi.com
The present research emphasizes fabrication alongside the assessment of an innovative
nano-vesicular membranous system known as invasomes (NVMs) laden with Mirtazapine …

Formulation and optimization of theophylline-loaded enteric-coated spanlastic nanovesicles for colon delivery; Ameliorate acetic acid-induced ulcerative colitis

EH Barakat, MA Akl, MF Ibrahim, HM Dawaba… - International Journal of …, 2023 - Elsevier
Abstract Treatment of colon diseases presents one of the most significant obstacles to drug
delivery due to the inability to deliver sufficient drug concentration selectively to the colon …

Formulation, and optimization of transdermal Atorvastatin Calcium-Loaded Ultra-flexible vesicles; ameliorates poloxamer 407-caused dyslipidemia

MA Akl, S Ryad, MF Ibrahim, AA Kassem - International Journal of …, 2023 - Elsevier
Atorvastatin calcium (AC), a cholesterol-lowering medication, has limited oral bioavailability
(14%) and adverse impacts on the gastrointestinal tract (GIT), liver, and muscle. So, in an …