Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and
venous occlusions. However, bleeding complications have also been observed in some …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background: Massive transfusion protocols (MTPs) have become standard of care in the
management of bleeding injured patients, yet strategies to guide them vary widely. We …

Patient blood management (PBM) is the timely application of evidence-informed medical
and surgical concepts designed to maintain haemoglobin concentration, optimise …

Initially described in 1948 by Hertert thromboelastography (TEG) provides a real‐time
assessment of viscoelastic clot strength in whole blood. Rotational thromboelastometry …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …

ORCA – Online Research @ Cardiff Page 1 ORCA – Online Research @ Cardiff This is an
Open Access document downloaded from ORCA, Cardiff University's institutional repository:https://orca.cardiff.ac.uk/id/eprint/115006 …

Ten percent of deaths worldwide are due to trauma, and it is the third most common cause of
death in the United States. Despite a profound upregulation in procoagulant mechanisms …