Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Sexual reproduction and meiotic sex are deeply rooted in the eukaryotic tree of life, but
mechanisms determining sex or mating types are extremely varied and are only well …

We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a
druggable target, using genetic and chemical validation. In vitro evolution of resistance with …

Differentiation from asexual blood stages to mature sexual gametocytes is required for the
transmission of malaria parasites. Here, we report that the ApiAP2 transcription factor, PfAP2 …

Dynamic control of gene expression is critical for blood stage development of malaria
parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the …

The virulence of Plasmodium falciparum, which causes the deadliest form of human malaria,
is attributed to its ability to evade the human immune response. These parasites “choose” to …

Various origin mapping approaches have enabled genome-wide identification of origins of
replication (ORI) in model organisms, but only a few studies have focused on divergent …

The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria
elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl …