Cell death or survival: Insights into the role of mRNA translational control
Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …
ability of mammalian cells to regulate global protein synthesis (aka translational control) …
The p53 mRNA: an integral part of the cellular stress response
L Haronikova, V Olivares-Illana, L Wang… - Nucleic acids …, 2019 - academic.oup.com
A large number of signalling pathways converge on p53 to induce different cellular stress
responses that aim to promote cell cycle arrest and repair or, if the damage is too severe, to …
responses that aim to promote cell cycle arrest and repair or, if the damage is too severe, to …
Transcriptome profiling of wheat genotypes under heat stress during grain-filling
High temperatures adversely impact productivity and quality (nutritional and functional) of
wheat grains. Anthesis and post-anthesis developmental stages are more sensitive to heat …
wheat grains. Anthesis and post-anthesis developmental stages are more sensitive to heat …
Translational regulation by upstream open reading frames and human diseases
J Silva, R Fernandes, L Romão - The mRNA Metabolism in Human …, 2019 - Springer
Short upstream open reading frames (uORFs) are cis-acting elements located within the 5′-
leader sequence of transcripts and are defined by an initiation codon in-frame with a …
leader sequence of transcripts and are defined by an initiation codon in-frame with a …
[HTML][HTML] Translation of SARS-CoV-2 gRNA is extremely efficient and competitive despite a high degree of secondary structures and the presence of an uORF
L Condé, O Allatif, T Ohlmann, S de Breyne - Viruses, 2022 - mdpi.com
The SARS-CoV-2 infection generates up to nine different sub-genomic mRNAs (sgRNAs), in
addition to the genomic RNA (gRNA). The 5′ UTR of each viral mRNA shares the first 75 …
addition to the genomic RNA (gRNA). The 5′ UTR of each viral mRNA shares the first 75 …
Insights into the evolution of the suppressors of cytokine signaling (SOCS) gene family in vertebrates
B Wang, E Wangkahart, CJ Secombes… - Molecular biology and …, 2019 - academic.oup.com
The SOCS family are key negative regulators of cytokine and growth factor signaling.
Typically, 8–17 SOCS genes are present in vertebrate species with eight known in …
Typically, 8–17 SOCS genes are present in vertebrate species with eight known in …
Alternative isoform expression of key thermogenic genes in human beige adipocytes
S Hazell Pickering, M Abdelhalim, P Collas… - Frontiers in …, 2024 - frontiersin.org
Background The beneficial effect of thermogenic adipocytes in maintaining body weight and
protecting against metabolic disorders has raised interest in understanding the regulatory …
protecting against metabolic disorders has raised interest in understanding the regulatory …
[HTML][HTML] No country for old methods: New tools for studying microproteins
F Valdivia-Francia, A Sendoel - Iscience, 2024 - ncbi.nlm.nih.gov
Microproteins encoded by small open reading frames (sORFs) have emerged as a
fascinating frontier in genomics. Traditionally overlooked due to their small size, recent …
fascinating frontier in genomics. Traditionally overlooked due to their small size, recent …
Plant responses to temperature stress modulated by microRNAs
Due to the increasing impact of worldwide environmental changes, temperature stress has
become a major factor resulting in crop yield losses. The discovery of temperature‐stress …
become a major factor resulting in crop yield losses. The discovery of temperature‐stress …
Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition
A Marques-Ramos, MM Candeias, J Menezes… - Rna, 2017 - rnajournal.cshlp.org
The mechanistic/mammalian target of rapamycin (mTOR) is a conserved serine/threonine
kinase that integrates cellular signals from the nutrient and energy status to act, namely, on …
kinase that integrates cellular signals from the nutrient and energy status to act, namely, on …