Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …

Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

While systemic lupus erythematosus (SLE) is an autoantibody and immune complex disease
by nature, most of its organ manifestations are in fact inflammatory. SLE activity scores thus …

Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …

Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is
structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and …

Detection of microbial products by multiprotein complexes known as inflammasomes is
pivotal to host defense against pathogens. Nucleotide-binding domain leucine-rich repeat …

The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform
involved in innate immunity required for the maturation and release of interleukin (IL)-1β and …

Objective Systemic lupus erythematosus (SLE), the most common form of lupus, is a
multisystemic rheumatic disease with different clinical features that generally affect women …

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease. The disease is
characterized by activation and dysregulation of both the innate and the adaptive immune …