The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …

Autophagy is a highly conserved process that maintains cellular homeostasis during
evolution. Autophagy can occur in the form of macroautophagy, microautophagy or …

Abstract N6-methyladenosine (m6A) is the most universal internal RNA modification on
messenger RNAs and regulates the fate and functions of m6A-modified transcripts through …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

Cardiac fibrosis, a well-known major pathological process that ultimately leads to heart
failure, has attracted increasing attention and focus in recent years. A large amount of …

Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …

Background LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa) and
autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy …

As a self-degradative mechanism, macroautophagy/autophagy has a role in the
maintenance of energy homeostasis during critical periods in the development of cells. It …