Non-invasive transcranial ultrasound stimulation for neuromodulation

G Darmani, TO Bergmann, KB Pauly, CF Caskey… - Clinical …, 2022 - Elsevier
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …

[HTML][HTML] Ultrasound neuromodulation: a review of results, mechanisms and safety

J Blackmore, S Shrivastava, J Sallet, CR Butler… - Ultrasound in medicine …, 2019 - Elsevier
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …

Ultrasound technologies for imaging and modulating neural activity

C Rabut, S Yoo, RC Hurt, Z Jin, H Li, H Guo, B Ling… - Neuron, 2020 - cell.com
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

S Yoo, DR Mittelstein, RC Hurt, J Lacroix… - Nature …, 2022 - nature.com
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …

Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation

K Yu, X Niu, E Krook-Magnuson, B He - Nature communications, 2021 - nature.com
Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its
mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct …

Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation

D Folloni, L Verhagen, RB Mars, E Fouragnan… - Neuron, 2019 - cell.com
The causal role of an area within a neural network can be determined by interfering with its
activity and measuring the impact. Many current reversible manipulation techniques have …

[HTML][HTML] Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans

W Legon, TF Sato, A Opitz, J Mueller, A Barbour… - Nature …, 2014 - nature.com
Improved methods of noninvasively modulating human brain function are needed. Here we
probed the influence of transcranial focused ultrasound (tFUS) targeted to the human …

Transcranial focused ultrasound stimulation of human primary visual cortex

W Lee, HC Kim, Y Jung, YA Chung, IU Song, JH Lee… - Scientific reports, 2016 - nature.com
Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of
regional brain stimulation. Current evidence of FUS-mediated neurostimulation for humans …

Neuromodulation with single‐element transcranial focused ultrasound in human thalamus

W Legon, L Ai, P Bansal, JK Mueller - Human brain mapping, 2018 - Wiley Online Library
Transcranial focused ultrasound (tFUS) has proven capable of stimulating cortical tissue in
humans. tFUS confers high spatial resolutions with deep focal lengths and as such, has the …

The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation

J Zhu, Q Xian, X Hou, KF Wong, T Zhu… - Proceedings of the …, 2023 - National Acad Sciences
Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …