The extraordinary rate accelerations and control of reactivity exhibited by enzymes have
long inspired efforts to develop synthetic catalysts. Foldamers, which are oligomers with a …

Non-natural folded polymers (foldamers) display considerable versatility, and the design of
such molecules is of great current interest. In this respect, peptidic foldamers are perhaps …

Foldamers are artificial folded molecular architectures inspired by the structures and
functions of biopolymers. This highlight focuses on important developments concerning …

Synthetic macromolecular antimicrobials are a highly promising class of therapeutics with
immense potential for combating multidrug resistant microbes. In contrast to conventional …

An enantioselective threecomponent radical reaction of quinolines or pyridines with
enamides and αbromo carbonyl compounds by dual photoredox and chiral Brønsted acid …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

Abstract γ-Amino acids and peptides analogues are common constituents of building blocks
for numerous biologically active molecules, pharmaceuticals, and natural products. In …

Recent years have witnessed an explosive growth in the field of amino organocatalysis,
especially in asymmetric enamine and iminium catalysis. Except for the obvious interaction …

Kinetic studies of the conjugate addition of propanal to nitrostyrene catalyzed by
diarylprolinol ethers reveal that formation of the product iminium species is rate-determining …

Stereoselective conjugate addition reactions of carbon-based nucleophiles are among the
most useful synthetic transformations.[1] Particularly challenging are CÀC bond forming …