The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …

Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Network reconstructions are a common denominator in systems biology. Bottom–up
metabolic network reconstructions have been developed over the last 10 years. These …

The human gut microbiota plays a central role in human well-being and disease. In this
study, we present an integrated, iterative approach of computational modeling, in vitro …

The need and opportunity to discover therapeutics for rare or orphan diseases are
enormous. Due to limited prevalence and/or commercial potential, of the approximately …

Human onchocerciasis is a serious neglected tropical disease caused by the filarial
nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of …

Metabolic network reconstructions represent valuable scaffolds for '-omics' data integration
and are used to computationally interrogate network properties. However, they do not …

An increasing number of genome‐scale reconstructions of intracellular biochemical
networks are being generated. Coupled with these stoichiometric models, several systems …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Background The increased sequencing of pathogen genomes and the subsequent
availability of genome-scale functional datasets are expected to guide the experimental …