Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Influenza virus infections pose a significant threat to public health due to annual seasonal
epidemics and occasional pandemics. Influenza is also associated with significant economic …

Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high
capacity for rapid development. Generation of a universal influenza virus vaccine with the …

Currently available influenza virus vaccines have inadequate effectiveness and are
reformulated annually due to viral antigenic drift. Thus, development of a vaccine that …

Influenza viruses are responsible for millions of cases globally and significantly threaten
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …

Despite advancements in immunotherapeutic approaches, influenza continues to cause
severe illness, particularly among immunocompromised individuals, young children, and …

Background Influenza viruses cause substantial annual morbidity and mortality globally.
Current vaccines protect against influenza only when well matched to the circulating strains …

Due to limitations of current influenza virus vaccines, new vaccines that mediate broad
protection and show high efficacy against seasonal and pandemic viruses are urgently …

There is an unmet public health need for a universal influenza vaccine (UIV) to provide
broad and durable protection from influenza virus infections. The identification of broadly …

Influenza virus has significant viral diversity, both through antigenic drift and shift, which
makes development of a vaccine challenging. Current influenza vaccines are updated …