Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

Skeletal muscles comprise the largest organ system in the body and play an essential role in
body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important …

Sepsis is a major cause of morbidity and mortality in critically ill patients, and despite
advances in management, mortality remains high. In survivors, sepsis increases the risk for …

Overproduction of the reactive oxygen species (ROS) superoxide (O2−) and hydrogen
peroxide (H2O2) are increasingly implicated in human disease and aging. ROS are also …

Several pathologies of the cardiovascular system are associated with an augmented
production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the …

Long periods of skeletal muscle inactivity promote a loss of muscle protein resulting in fiber
atrophy. This disuse-induced muscle atrophy results from decreased protein synthesis and …

Peroxynitrite is a reactive oxygen and nitrogen species that participates in various biological
reactions. Therefore, it is important to readily detect and track peroxynitrite in biological …

Acute kidney injury is a frequent and serious complication of sepsis. To better understand
the development of sepsis-induced acute kidney injury, we performed the first time …

Nitric oxide participates in a wide array of physiological processes, ranging from
neurotransmission to precursor of cytotoxic effector molecules of the immune system …