Flavones: An important scaffold for medicinal chemistry

M Singh, M Kaur, O Silakari - European journal of medicinal chemistry, 2014 - Elsevier
Flavones have antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl
cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular …

Antimalarials from nature

K Kaur, M Jain, T Kaur, R Jain - Bioorganic & medicinal chemistry, 2009 - Elsevier
Malaria is a major public health problem mainly due to the development of resistance by the
most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like …

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway

H Lu, PJ Tonge - Accounts of chemical research, 2008 - ACS Publications
The modern age of drug discovery, which had been slowly gathering momentum during the
early part of the twentieth century, exploded into life in the 1940s with the isolation of …

Flavonoids as a Natural Treatment Against Entamoeba histolytica

M Martínez-Castillo, J Pacheco-Yepez… - Frontiers in cellular …, 2018 - frontiersin.org
Over the past 20 years, gastrointestinal infections in developing countries have been a
serious health problem and are the second leading cause of morbidity among all age …

Discovery of a Rhodanine Class of Compounds as Inhibitors of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase

G Kumar, P Parasuraman, SK Sharma… - Journal of medicinal …, 2007 - ACS Publications
Enoyl acyl carrier protein (ACP) reductase, one of the enzymes of the type II fatty acid
biosynthesis pathway, has been established as a promising target for the development of …

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase [S]

M Cuccioloni, M Mozzicafreddo, M Spina, CN Tran… - Journal of lipid …, 2011 - ASBMB
Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is the rate-controlling enzyme of
cholesterol synthesis, and owing to its biological and pharmacological relevance …

Quercetin as a promising antiprotozoan phytochemical: current knowledge and future research avenues

H Memariani, M Memariani… - BioMed Research …, 2024 - Wiley Online Library
Despite tremendous advances in the prevention and treatment of infectious diseases, only
few antiparasitic drugs have been developed to date. Protozoan infections such as malaria …

Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II

AK Brown, A Papaemmanouil, V Bhowruth… - …, 2007 - microbiologyresearch.org
Flavonoids comprise a large group of bioactive polyphenolic plant secondary metabolites.
Several of these possess potent in vivo activity against Escherichia coli and Plasmodium …

Natural phenolic compounds and derivatives as potential antimalarial agents

L Mamede, A Ledoux, O Jansen, M Frédérich - Planta medica, 2020 - thieme-connect.com
Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for
hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent …

(−)-Epigallocatechin 3-gallate synthetic analogues inhibit fatty acid synthase and show anticancer activity in triple negative breast cancer

J Crous-Masó, S Palomeras, J Relat, C Camó… - Molecules, 2018 - mdpi.com
(−)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported
anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN) …