Bioinspired Spatiotemporal Management toward RNA Therapies
Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …
intervention, especially with some that have been approved by the FDA such as the mRNA …
Telomerase is not an oncogene
CB Harley - Oncogene, 2002 - nature.com
In the decade since the telomere hypothesis of cellular aging was proposed, the two
essential genes for human telomerase were cloned and characterized, allowing …
essential genes for human telomerase were cloned and characterized, allowing …
[HTML][HTML] Development of a conditionally immortalized human pancreatic β cell line
R Scharfmann, S Pechberty, Y Hazhouz… - The Journal of …, 2014 - Am Soc Clin Investig
Diabetic patients exhibit a reduction in β cells, which secrete insulin to help regulate glucose
homeostasis; however, little is known about the factors that regulate proliferation of these …
homeostasis; however, little is known about the factors that regulate proliferation of these …
Production and titration of lentiviral vectors
Lentiviral vectors have emerged over the last decade as powerful, reliable, and safe tools for
stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from …
stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from …
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis
NB Woods, A Muessig, M Schmidt… - Blood, The Journal …, 2003 - ashpublications.org
Efficient vector transduction of hematopoietic stem cells is a requirement for successful gene
therapy of hematologic disorders. We asked whether human umbilical cord blood CD34+ …
therapy of hematologic disorders. We asked whether human umbilical cord blood CD34+ …
Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo
The Cre recombinase (Cre) from bacteriophage P1 is an important tool for genetic
engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre …
engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre …
Agonists of prostaglandin E2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies
H Garcia, AS Serafin, F Silbermann… - Proceedings of the …, 2022 - National Acad Sciences
Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging
to the ciliopathy disorders and known as the most common cause of hereditary end-stage …
to the ciliopathy disorders and known as the most common cause of hereditary end-stage …
[HTML][HTML] Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids
and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains …
and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains …
Production and titration of lentiviral vectors
Lentiviral vectors have emerged over the last decade as powerful, reliable and safe tools for
stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from …
stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from …
Drug transporters on arachnoid barrier cells contribute to the blood–cerebrospinal fluid barrier
K Yasuda, C Cline, P Vogel, M Onciu, S Fatima… - Drug Metabolism and …, 2013 - ASPET
The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal
cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF …
cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF …