Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …

In the decade since the telomere hypothesis of cellular aging was proposed, the two
essential genes for human telomerase were cloned and characterized, allowing …

Diabetic patients exhibit a reduction in β cells, which secrete insulin to help regulate glucose
homeostasis; however, little is known about the factors that regulate proliferation of these …

Lentiviral vectors have emerged over the last decade as powerful, reliable, and safe tools for
stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from …

Efficient vector transduction of hematopoietic stem cells is a requirement for successful gene
therapy of hematologic disorders. We asked whether human umbilical cord blood CD34+ …

The Cre recombinase (Cre) from bacteriophage P1 is an important tool for genetic
engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre …

Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging
to the ciliopathy disorders and known as the most common cause of hereditary end-stage …

TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids
and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains …

Lentiviral vectors have emerged over the last decade as powerful, reliable and safe tools for
stable gene transfer in a wide variety of mammalian cells. Unlike other vectors derived from …

The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal
cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF …