Supramolecular adhesive hydrogels for tissue engineering applications
Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the
loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and …
loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and …
[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
[HTML][HTML] Progression in translational research on spinal cord injury based on microenvironment imbalance
B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …
and imposes a considerable burden on patients, families, and society. Repair of the injured …
[HTML][HTML] Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 …
W Liu, Y Rong, J Wang, Z Zhou, X Ge, C Ji… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with
high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano …
high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano …
Natural and targeted circuit reorganization after spinal cord injury
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury
L Li, Y Zhang, J Mu, J Chen, C Zhang, H Cao, J Gao - Nano letters, 2020 - ACS Publications
Spinal cord injury is among the most fatal diseases. The complicated inhibitory
microenvironment requires comprehensive mitigation. Exosomes derived from …
microenvironment requires comprehensive mitigation. Exosomes derived from …
Spinal cord repair: advances in biology and technology
G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …
Advances in clinical management have decreased morbidity and improved outcomes, but …
The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126
W Liu, L Li, Y Rong, D Qian, J Chen, Z Zhou, Y Luo… - Acta biomaterialia, 2020 - Elsevier
Increasing evidence has suggested that paracrine mechanisms might be involved in the
underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes …
underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes …