Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …

Hair follicles are essential appendages of the mammalian skin, as hair performs vital
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

Stem cells regenerate tissues in homeostasis and under stress. By taking cues from their
microenvironment or" niche," they smoothly transition between these states. Immune cells …