Epigenomic and other evidence for cannabis-induced aging contextualized in a synthetic epidemiologic overview of cannabinoid-related teratogenesis and …
AS Reece, GK Hulse - … Journal of Environmental Research and Public …, 2022 - mdpi.com
Background: Twelve separate streams of empirical data make a strong case for cannabis-
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …
DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
[HTML][HTML] Genetic and epigenetic background of diabetic kidney disease
N Sandholm, EH Dahlström, PH Groop - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development
Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …
development, as they not only reflect metabolic changes but are also preserved and …
Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes
I Khurana, H Kaipananickal, S Maxwell… - The Journal of …, 2023 - Am Soc Clin Investig
Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust
replication in large-scale genome-wide association studies. To understand the role of DNA …
replication in large-scale genome-wide association studies. To understand the role of DNA …
DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation
Recent epigenome-wide studies suggest an association between blood DNA methylation
and kidney function. However, the pathological importance remains unclear. Here, we show …
and kidney function. However, the pathological importance remains unclear. Here, we show …
Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
Identifying genomic regions pertinent to complex traits is a common goal of genome-wide
and epigenome-wide association studies (GWAS and EWAS). GWAS identify causal genetic …
and epigenome-wide association studies (GWAS and EWAS). GWAS identify causal genetic …
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes
Z Chen, E Satake, MG Pezzolesi, ZI Md Dom… - Science translational …, 2024 - science.org
Variation in DNA methylation (DNAmet) in white blood cells and other cells/tissues has been
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …
Nucleic acid and protein methylation modification in renal diseases
J Jin, X Liu, W Shao, X Meng - Acta Pharmacologica Sinica, 2024 - nature.com
Although great efforts have been made to elucidate the pathological mechanisms of renal
diseases and potential prevention and treatment targets that would allow us to retard kidney …
diseases and potential prevention and treatment targets that would allow us to retard kidney …