Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

Videos of animal behavior are used to quantify researcher-defined behaviors of interest to
study neural function, gene mutations, and pharmacological therapies. Behaviors of interest …

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile
information to sensory neurons. However, the specific mechanotransducers that enable …

Mechanosensation is the ability to detect dynamic mechanical stimuli (eg, pressure, stretch,
and shear stress) and is essential for a wide variety of processes, including our sense of …

Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …

Pleasurable touch is paramount during social behavior, including sexual encounters.
However, the identity and precise role of sensory neurons that transduce sexual touch …

Across mammalian skin, structurally complex and diverse mechanosensory end organs
respond to mechanical stimuli and enable our perception of dynamic, light touch. How forces …

The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are
poorly defined, hindering our understanding of their roles in normal physiology and …