Lessons from the host defences of bats, a unique viral reservoir
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Big data's role in precision public health
S Dolley - Frontiers in public health, 2018 - frontiersin.org
Precision public health is an emerging practice to more granularly predict and understand
public health risks and customize treatments for more specific and homogeneous …
public health risks and customize treatments for more specific and homogeneous …
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
FJ Salguero, AD White, GS Slack… - Nature …, 2021 - nature.com
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
The Egyptian rousette genome reveals unexpected features of bat antiviral immunity
SS Pavlovich, SP Lovett, G Koroleva, JC Guito… - Cell, 2018 - cell.com
Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …
virulence in humans. To identify differences between antiviral mechanisms in humans and …
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation
and pathology of multiple organs in individuals under 21 years of age in the weeks following …
and pathology of multiple organs in individuals under 21 years of age in the weeks following …
[HTML][HTML] Improving vaccine-induced immunity: can baseline predict outcome?
JS Tsang, C Dobaño, P VanDamme, G Moncunill… - Trends in …, 2020 - cell.com
Immune signatures measured at baseline and immediately prior to vaccination may predict
the immune response to vaccination. Such pre-vaccine assessment might allow not only …
the immune response to vaccination. Such pre-vaccine assessment might allow not only …
Understanding virus–host interactions in tissues
E Speranza - Nature Microbiology, 2023 - nature.com
Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …
in immortalized cell lines or isolated cell populations, it is important to remember that what is …
Single-cell profiling of Ebola virus disease in vivo reveals viral and host dynamics
Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to
the challenge of experimentation in high-containment and outbreak settings. Here, we used …
the challenge of experimentation in high-containment and outbreak settings. Here, we used …
Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens
A Fathi, C Dahlke, MM Addo - Human vaccines & …, 2019 - Taylor & Francis
The devastating Ebola virus (EBOV) outbreak in West Africa in 2013–2016 has flagged the
need for the timely development of vaccines for high-threat pathogens. To be better …
need for the timely development of vaccines for high-threat pathogens. To be better …