Lessons from the host defences of bats, a unique viral reservoir

AT Irving, M Ahn, G Goh, DE Anderson, LF Wang - Nature, 2021 - nature.com
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …

Big data's role in precision public health

S Dolley - Frontiers in public health, 2018 - frontiersin.org
Precision public health is an emerging practice to more granularly predict and understand
public health risks and customize treatments for more specific and homogeneous …

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

M Ahn, DE Anderson, Q Zhang, CW Tan, BL Lim… - Nature …, 2019 - nature.com
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …

Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

FJ Salguero, AD White, GS Slack… - Nature …, 2021 - nature.com
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …

The Egyptian rousette genome reveals unexpected features of bat antiviral immunity

SS Pavlovich, SP Lovett, G Koroleva, JC Guito… - Cell, 2018 - cell.com
Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

ND Beckmann, PH Comella, E Cheng, L Lepow… - Nature …, 2021 - nature.com
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation
and pathology of multiple organs in individuals under 21 years of age in the weeks following …

[HTML][HTML] Improving vaccine-induced immunity: can baseline predict outcome?

JS Tsang, C Dobaño, P VanDamme, G Moncunill… - Trends in …, 2020 - cell.com
Immune signatures measured at baseline and immediately prior to vaccination may predict
the immune response to vaccination. Such pre-vaccine assessment might allow not only …

Understanding virus–host interactions in tissues

E Speranza - Nature Microbiology, 2023 - nature.com
Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …

Single-cell profiling of Ebola virus disease in vivo reveals viral and host dynamics

D Kotliar, AE Lin, J Logue, TK Hughes, NM Khoury… - Cell, 2020 - cell.com
Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to
the challenge of experimentation in high-containment and outbreak settings. Here, we used …

Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens

A Fathi, C Dahlke, MM Addo - Human vaccines & …, 2019 - Taylor & Francis
The devastating Ebola virus (EBOV) outbreak in West Africa in 2013–2016 has flagged the
need for the timely development of vaccines for high-threat pathogens. To be better …