Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

The prognostic value of FoxP3+ regulatory T cells (Tregs) in cancer remains controversial.
We did a meta-analysis to assess the prognostic effect of FoxP3+ Treg across different types …

Interactions between immune and malignant cells have been known to have clinical
relevance for decades. The potential for immune control is now being therapeutically …

Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by
hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to …

Purpose: The efficacy of PD-1 checkpoint blockade as adjuvant therapy in localized clear
cell renal cell carcinoma (ccRCC) is currently unknown. The identification of tumor …

Background: Tumour-infiltrating lymphocytes (TILs) are often found in tumours, presumably
reflecting an immune response against the tumour. We carried out a systematic review and …

Abstract CD8+ tumor-infiltrating lymphocytes (TIL) are associated with survival in a variety of
cancers. A second subpopulation of TIL, defined by forkhead box protein P3 (FoxP3) …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …

CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …