Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and
progression of disease. Signs of inflammation can be observed in joint fluids and tissues …

Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Objective To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal
transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis …

Osteoarthritis (OA) is a common joint condition that is a leading cause of disability
worldwide. There are currently no disease-modifying treatments for osteoarthritis, which is …

Post-traumatic arthritis (PTA) develops after an acute direct trauma to the joints. PTA causes
about 12% of all osteoarthritis cases, and a history of physical trauma may also be found in …

Objectives Synovium is acutely affected following joint trauma and contributes to post-
traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and …

Synovitis, a common clinical symptom for osteoarthritis (OA) patients, is highly related to OA
pathological progression and pain manifestation. The activated synovial macrophages have …

Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence
suggests that dysregulated innate immunity is likely involved. Here, we performed …

This review highlights a selection of recently published literature in the area of osteoarthritis
biology. Major themes transpiring from a PubMed search covering the year between the …