A growing body of research has identified circadian-rhythm disruption as a risk factor for
metabolic health. However, the underlying biological basis remains complex, and complete …

This paper comprises an updated version of the 2014 review which reported 1846 volatile
organic compounds (VOCs) identified from healthy humans. In total over 900 additional …

The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

Metabolic diseases are often characterized by circadian misalignment in different tissues,
yet how altered coordination and communication among tissue clocks relate to specific …

On-line analysis of exhaled breath offers insight into a person's metabolism without the need
for sample preparation or sample collection. Due to its noninvasive nature and the possibility …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

The circadian clock directs nearly all aspects of diurnal physiology, including metabolism.
Current research identifies several major axes by which it exerts these effects, including …

Study Objectives A critical barrier to successful treatment of circadian misalignment in shift
workers is determining circadian phase in a clinical or field setting. Light and movement data …

Physiological function, disease expression and drug effects vary by time-of-day. Clock
disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; …