Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

The intrinsic ability of neurogenesis after stroke has been proven weak, which results in
insufficient repair of injury in the nerve system. Recent studies suggest multiple microRNAs …

Cooling can reduce primary injury and prevent secondary injury to the brain after insults in
certain clinical settings and in animal models of brain insult. The mechanisms that underlie …

Neurogenesis is restricted in the adult mammalian brain; most neurons are neither
exchanged during normal life nor replaced in pathological situations. We report that stroke …

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also
called subependymal zone) generate doublecortin (Dcx)+ neuroblasts that migrate and …

Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …

Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ)
and induces ectopic migration of newborn cells towards the site of injury. Here, we …

Therapeutic hypothermia, or cooling of the body or brain for the purposes of preserving
organ viability, is one of the most robust neuroprotectants at both the preclinical and clinical …