Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator
P Puigserver, BM Spiegelman - Endocrine reviews, 2003 - academic.oup.com
Investigations of biological programs that are controlled by gene transcription have mainly
studied the regulation of transcription factors. However, there are examples in which the …
studied the regulation of transcription factors. However, there are examples in which the …
RNA polymerase II elongation control
Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …
[HTML][HTML] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
P Puigserver, Z Wu, CW Park, R Graves, M Wright… - Cell, 1998 - cell.com
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic
defense against obesity. We have cloned a novel transcriptional coactivator of nuclear …
defense against obesity. We have cloned a novel transcriptional coactivator of nuclear …
The SR protein family of splicing factors: master regulators of gene expression
JC Long, JF Caceres - Biochemical Journal, 2009 - portlandpress.com
The SR protein family comprises a number of phylogenetically conserved and structurally
related proteins with a characteristic domain rich in arginine and serine residues, known as …
related proteins with a characteristic domain rich in arginine and serine residues, known as …
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid …
Peroxisome proliferator-activated receptor α (PPARα) plays a key role in the transcriptional
control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study …
control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study …
The general transcription machinery and general cofactors
MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
The RNA polymerase II CTD coordinates transcription and RNA processing
The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …
Structure of a transcribing RNA polymerase II–U1 snRNP complex
S Zhang, S Aibara, SM Vos, DE Agafonov, R Lührmann… - Science, 2021 - science.org
To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear
ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA) …
ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA) …
The HIV-1 rev protein
VW Pollard, MH Malim - Annual review of microbiology, 1998 - annualreviews.org
▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …
Systematic identification of novel protein domain families associated with nuclear functions
T Doerks, RR Copley, J Schultz, CP Ponting… - Genome …, 2002 - genome.cshlp.org
A systematic computational analysis of protein sequences containing known nuclear
domains led to the identification of 28 novel domain families. This represents a 26 …
domains led to the identification of 28 novel domain families. This represents a 26 …