Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

Thermogenesis by brown and beige adipose tissue, which requires activation by external
stimuli, can counter metabolic disease. Thermogenic respiration is initiated by adipocyte …

In response to skeletal muscle contraction during exercise, paracrine factors coordinate
tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …

Metastatic cancer is difficult to cure because of its uncontrollable nature and side effects
during treatment. We constructed a reactive oxygen species (ROS)‐activated smart …

Leigh syndrome is a rare, complex, and incurable early onset (typically infant or early
childhood) mitochondrial disorder with both phenotypic and genetic heterogeneity. The …

During heart transplantation, storage in cold preservation solution is thought to protect the
organ by slowing metabolism, providing osmotic support and minimizing ischaemia …

In the context of myocardial infarction, the burst of superoxide generated by reverse electron
transport (RET) at complex I in mitochondria is a crucial trigger for damage during …