A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein
homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Background Pancreatic β cell dysfunction and death are central in the pathogenesis of most
if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell …

Pancreatic β cell neogenesis and proliferation during the neonatal period are critical for the
generation of sufficient pancreatic β cell mass/reserve and have a profound impact on long …

The unfolded protein response (UPR) is a signal transduction pathway that coordinates
cellular adaptation to microenvironmental stresses that include hypoxia, nutrient deprivation …

Regulation of mRNA translation is a rapid and effective means to couple changes in the
cellular environment with global rates of protein synthesis. In response to stresses, such as …

In response to environmental stresses, a family of protein kinases phosphorylate eIF2
(eukaryotic initiation factor 2) to alleviate cellular injury or alternatively induce apoptosis …

Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the
pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance …