Long-read sequencing technologies have now reached a level of accuracy and yield that
allows their application to variant detection at a scale of tens to thousands of samples …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Genome-scale sequence data have invigorated the study of hybridization and introgression,
particularly in animals. However, outside of a few notable cases, we lack systematic tests for …

Pangenomes provide access to an accurate representation of the genetic diversity of
species, both in terms of sequence polymorphisms and structural variants (SVs). Here we …

The silkworm Bombyx mori is an important economic insect for producing silk, the “queen of
fabrics”. The currently available genomes limit the understanding of its genetic diversity and …

Studies of genome regulation routinely use high-throughput DNA sequencing approaches to
determine where specific proteins interact with DNA, and they rely on DNA amplification and …

Long-read sequencing is driving rapid progress in genome assembly across all major
groups of life, including species of the family Drosophilidae, a longtime model system for …

Antimicrobial peptides are host-encoded immune effectors that combat pathogens and
shape the microbiome in plants and animals. However, little is known about how the host …

Hemocytes, similar to vertebrate blood cells, play important roles in insect development and
immunity, but it is not well understood how they perform their tasks. New technology, in …

As the accuracy and throughput of nanopore sequencing improve, it is increasingly common
to perform long-read first de novo genome assemblies followed by polishing with accurate …