Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

RL Charlton, B Rossi-Bergmann, PW Denny, PG Steel - Parasitology, 2018 - cambridge.org
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites
of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs …

Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi

G Benaim, AE Paniz-Mondolfi, EM Sordillo… - Frontiers in cellular …, 2020 - frontiersin.org
There is no effective cure for Chagas disease, which is caused by infection with the
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …

Mechanism of action of miltefosine on Leishmania donovani involves the impairment of acidocalcisome function and the activation of the sphingosine-dependent …

AK Pinto-Martinez, J Rodriguez-Durán… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Leishmania donovani is the causing agent of visceral leishmaniasis, a common infection
that affects millions of people from the most underdeveloped countries. Miltefosine is the …

The current directions of searching for antiparasitic drugs

K Dziduch, D Greniuk, M Wujec - Molecules, 2022 - mdpi.com
Parasitic diseases are still a huge problem for mankind. They are becoming the main cause
of chronic diseases in the world. Migration of the population, pollution of the natural …

Trypanosomatid parasites causing neglected diseases

K Nussbaum, J Honek, CC Cadmus… - Current medicinal …, 2010 - ingentaconnect.com
Parasitic diseases such as Kala azar (visceral leishmaniasis), Chagas disease (American
trypanosomiasis) and African sleeping sickness (human African trypanosomiasis) are …

Drug resistance in leishmaniasis: current drug-delivery systems and future perspectives

M Yasinzai, M Khan, A Nadhman… - Future medicinal …, 2013 - Taylor & Francis
Leishmaniasis is a complex of diseases with numerous clinical manifestations for instance
harshness from skin lesions to severe disfigurement and chronic systemic infection in the …

A current perspective on leishmaniasis

A Clem - Journal of global infectious diseases, 2010 - journals.lww.com
There are many challenges facing the successful control and eradication of cutaneous and
visceral leishmaniasis. Leishmaniasis is still endemic in many poverty stricken and war torn …

Biocompatible silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine

SK Kalangi, A Dayakar, D Gangappa… - Experimental …, 2016 - Elsevier
Despite the existence of chemotherapy, there is no effective cure for leishmaniasis. In the
light of recommended therapeutic regimen is attributed for toxicity and development of …

New antileishmanial candidates and lead compounds

JV Richard, KA Werbovetz - Current opinion in chemical biology, 2010 - Elsevier
Although miltefosine and paromomycin were registered as clinical agents against visceral
leishmaniasis in the last decade, the antileishmanial drug arsenal still requires …

Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis

ST Macedo-Silva, TLA Oliveira Silva… - Molecular biology …, 2011 - Wiley Online Library
Amiodarone (AMIO), the most frequently antiarrhythmic drug used for the symptomatic
treatment of chronic Chagas′ disease patients with cardiac compromise, has recently been …