Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Malaria accounts for over two million deaths globally. To flatten this curve, there is a need to
develop new and high potent drugs against Plasmodium falciparum. Some major …

The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …

Background Emergence of cross-resistance to current anti-malarial drugs has led to an
urgent need for identification of potential compounds with novel modes of action and anti …

The growing evidences of resistant fungi stimulate fully understanding tebuconazole
regarding its crystal structure on fungicidal activity. In this study, the crystal structures of six …

Identification of lead compounds with the traditional laboratory approach is expensive and
time-consuming. Nowadays, in silico techniques have emerged as a promising approach for …

Since the discovery of dicoumarol (a coumarin-based anticoagulant) in 1940, coumarins
have been found to possess a range of biological activities such as antimicrobial, anti …

The increasing resistance of the malarial parasite to readily available drugs ensures a
continuous battle against endemic diseases. Hence, the search for antimalarial drugs with …

Aldose reductase is an oxo-reductase enzyme belonging to the aldo-keto reductase class.
Compounds having thiazolidine-2, 4-dione scaffold are reported as potential aldose …

Adverse drug reactions represent a major health burden because they cause notable patient
morbidity and mortality. From this viewpoint, several strategies have been developed to …