[HTML][HTML] The challenge by multiple environmental and biological factors induce inflammation in aging: their role in the promotion of chronic disease

MC Bachmann, S Bellalta, R Basoalto… - Frontiers in …, 2020 - frontiersin.org
The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Respiratory syncytial virus infection: why does disease severity vary among individuals?

A Tahamtan, S Samadizadeh, M Rastegar… - Expert review of …, 2020 - Taylor & Francis
Introduction: Respiratory syncytial virus (RSV) is the most common cause of acute lower
respiratory tract infections in infancy. While many infants are infected with RSV, the nature …

Severe respiratory disease among children with and without medical complexity during the COVID-19 pandemic

C Belza, E Pullenayegum, KE Nelson… - JAMA Network …, 2023 - jamanetwork.com
Importance Severe respiratory disease declined during the COVID-19 pandemic, partially
due to decreased circulation of respiratory pathogens. However, the outcomes of children …

Its all about IFN‐λ4: Protective role of IFNL4 polymorphism against COVID‐19‐related pneumonia in females

S Matic, D Milovanovic, Z Mijailovic… - Journal of Medical …, 2023 - Wiley Online Library
Despite the pivotal role of IFN‐λs in the innate immune response, the data on its genetic
polymorphism in relation to COVID‐19 severity are scarce and contradictory. In the present …

Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes

M De, A Bhushan… - Journal of leukocyte …, 2021 - academic.oup.com
Human IFN-λ4 is expressed by only a subset of individuals who possess the ΔG variant
allele at the dinucleotide polymorphism rs368234815. Recent genetic studies have shown …

Gender‐dependent multiple cross‐phenotype association of interferon lambda genetic variants with peripheral blood profiles in healthy individuals

DG Roy, L Singh, HK Chaturvedi… - Molecular genetics & …, 2024 - Wiley Online Library
Abstract Background Type III interferons (IFN), also called as lambda IFNs (IFN‐λs), are
antiviral and immunomodulatory cytokines that are evolutionarily important in humans …

Respiratory syncytial virus: host genetic susceptibility and factors associated with disease severity in a cohort of pediatric patients

H IG Giamberardino, AP O. Pacheco… - Journal of Tropical …, 2022 - academic.oup.com
Background Respiratory syncytial virus (RSV) infections are the leading cause of
hospitalization in young children. We assessed the epidemiology, severity, clinical …

Influenza A infections: predictors of disease severity

LA Pereira, BA Lapinscki, JS Santos, MC Debur… - Brazilian Journal of …, 2024 - Springer
Influenza affects approximately 10% of the world's population annually. It is associated with
high morbidity and mortality rates due to its propensity to progress to severe acute …

Association Between IL28B, IL29 Gene Polymorphisms and Clinical Manifestations of Behçet's Disease

G Cakmak Genc, S Karakas Celık… - Immunological …, 2021 - Taylor & Francis
Background Behçet's disease (BD) is a chronic, multisystemic, inflammatory disease
characterized by relapsing episodes of a wide spectrum of clinical findings. The role and …

[PDF][PDF] Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-𝝀3 or IFN-𝝀4 show distinct phenotypes

M De, A Bhushan, S Chinnaswamy - researchgate.net
Human IFN-𝜆4 is expressed by only a subset of individuals who possess the ΔG variant
allele at the dinucleotide polymorphism rs368234815. Recent genetic studies have shown …