[HTML][HTML] TLR4 signaling in the development of colitis-associated cancer and its possible interplay with microRNA-155
J Guo, M Liao, J Wang - Cell Communication and Signaling, 2021 - Springer
Ulcerative colitis (UC) has closely been associated with an increased risk of colorectal
cancer. However, the exact mechanisms underlying colitis-associated cancer (CAC) …
cancer. However, the exact mechanisms underlying colitis-associated cancer (CAC) …
[HTML][HTML] Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
W Dai, L Long, X Wang, S Li, H Xu - Chinese Medicine, 2022 - Springer
Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases including
Crohn's disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key …
Crohn's disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key …
[PDF][PDF] Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …
[HTML][HTML] Peptostreptococcus anaerobius induces intracellular cholesterol biosynthesis in colon cells to induce proliferation and causes dysplasia in mice
Background & Aims Stool samples from patients with colorectal cancer (CRC) have a higher
abundance of Peptostreptococcus anaerobius than stool from individuals without CRC …
abundance of Peptostreptococcus anaerobius than stool from individuals without CRC …
[HTML][HTML] In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses
There is a need for functional in vitro 3D human intestine systems that can bridge the gap
between conventional cell culture studies and human trials. The successful engineering in …
between conventional cell culture studies and human trials. The successful engineering in …
Lipopolysaccharide from crypt-specific core microbiota modulates the colonic epithelial proliferation-to-differentiation balance
T Naito, C Mulet, C De Castro, A Molinaro, A Saffarian… - MBio, 2017 - Am Soc Microbiol
We identified a crypt-specific core microbiota (CSCM) dominated by strictly aerobic,
nonfermentative bacteria in murine cecal and proximal colonic (PC) crypts and hypothesized …
nonfermentative bacteria in murine cecal and proximal colonic (PC) crypts and hypothesized …
[HTML][HTML] Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation
Gastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer
treatment–induced mucositis and ulcerative colitis. These disorders cause debilitating …
treatment–induced mucositis and ulcerative colitis. These disorders cause debilitating …
[HTML][HTML] The molecular mechanisms of intestinal inflammation and fibrosis in Crohn's disease
Y Hayashi, H Nakase - Frontiers in physiology, 2022 - frontiersin.org
Crohn's disease (CD) is an inflammatory bowel disease (IBD) with repeated remissions and
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …
[HTML][HTML] Mechanisms of microbe–host interaction in Crohn's disease: dysbiosis vs. pathobiont selection
Crohn's disease (CD) is a systemic chronic inflammatory condition mainly characterized by
discontinuous transmural pathology of the gastrointestinal tract and frequent extraintestinal …
discontinuous transmural pathology of the gastrointestinal tract and frequent extraintestinal …
High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge
R Grosick, PA Alvarado-Vazquez… - Journal of pain …, 2018 - Taylor & Francis
Introduction Painful diabetic neuropathy is associated with chronic inflammation, in which
macrophages are the key effectors. We utilized an in vitro approach to determine the effects …
macrophages are the key effectors. We utilized an in vitro approach to determine the effects …