Excessive airway obstruction is the cause of symptoms and abnormal lung function in
asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is …

Studies in animal models form the basis for much of our current understanding of the
pathophysiology of asthma, and are central to the preclinical development of drug therapies …

In asthma, the mechanisms relating airway obstruction, hyperresponsiveness, and
inflammation remain rather mysterious. We show here that regulation of airway smooth …

Asthma is a chronic inflammatory disease of the airway with extensive airway remodeling.
The ethical issues associated with the studies in asthmatic patients, required development of …

Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …

Despite the lack of a clearly defined physiological function, airway smooth muscle receives
substantial attention because of its involvement in the pathogenesis of asthma. Recent …

Airway hyperresponsiveness is a cardinal feature of asthma but remains largely
unexplained. In asthma, the key end-effector of acute airway narrowing is the airway smooth …

Rationale: Airway smooth muscle (ASM) plays a key role in airway hyperresponsiveness
(AHR) but it is unclear whether its contractility is intrinsically changed in asthma. Objectives …

To investigate the relationship between bronchial responsiveness and airway smooth-
muscle (ASM) contractile properties, we studied inbred mice with known interstrain …

Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In
asthma, the airway smooth muscle cell is the key end-effector of bronchospasm and acute …