Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology.
Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Little is known about the identity of endoplasmic reticulum (ER) export signals and how they
are used to regulate the number of proteins on the cell surface. Here, we describe two ER …

G‐protein regulated inward‐rectifier potassium channels (GIRK) are part of a superfamily of
inward‐rectifier K+ channels which includes seven family members. To date four GIRK …

Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac
death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been …

OBJECTIVES We sought to study the role of IKAChin atrial fibrillation (AF) and the potential
electrophysiologic effects of a specific IKAChantagonist. BACKGROUND IKAChmediates …

In the mammalian myocardium, potassium (K+) channels control resting potentials, action
potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple …