The regulation and functions of DNA and RNA G-quadruplexes

D Varshney, J Spiegel, K Zyner, D Tannahill… - … reviews Molecular cell …, 2020 - nature.com
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …

RNA G-quadruplexes in biology: principles and molecular mechanisms

MM Fay, SM Lyons, P Ivanov - Journal of molecular biology, 2017 - Elsevier
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

Whole genome experimental maps of DNA G-quadruplexes in multiple species

G Marsico, VS Chambers, AB Sahakyan… - Nucleic acids …, 2019 - academic.oup.com
Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these
secondary structures play in various organisms. Herein, we employ an improved version of a …

RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection

G Liu, W Du, X Sang, Q Tong, Y Wang, G Chen… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …

G-quadruplexes: prediction, characterization, and biological application

CK Kwok, CJ Merrick - Trends in biotechnology, 2017 - cell.com
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

G-Quadruplexes in RNA biology: recent advances and future directions

L Dumas, P Herviou, E Dassi, A Cammas… - Trends in Biochemical …, 2021 - cell.com
RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene expression
mechanisms, from transcription to protein synthesis, and DNA-related processes. Their …

A guide to computational methods for G-quadruplex prediction

E Puig Lombardi, A Londoño-Vallejo - Nucleic acids research, 2020 - academic.oup.com
Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …

Cancer transcriptome profiling at the juncture of clinical translation

M Cieślik, AM Chinnaiyan - Nature Reviews Genetics, 2018 - nature.com
Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …