Caenorhabditis elegans has emerged as a major model in biomedical and environmental
toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been …

Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

Dysregulation of the immune system is a cardinal feature of opioid addiction. Here, we
characterize the landscape of peripheral immune cells from patients with opioid use disorder …

G protein-coupled receptors (GPCRs) mediate responses to various extracellular and
intracellular cues. However, the large number of GPCR genes and their substantial …

Defense against intracellular infection has been extensively studied in vertebrate hosts, but
less is known about invertebrate hosts; specifically, the transcription factors that induce …

The model organism Caenorhabditis elegans mounts transcriptional defense responses
against intestinal bacterial infections that elicit overlapping starvation and infection …

The response to insufficient oxygen (hypoxia) is orchestrated by the conserved hypoxia-
inducible factor (HIF). However, HIF-independent hypoxia response pathways exist that act …

Animals possess conserved mechanisms to detect pathogens and to improve survival in
their presence by altering their own behavior and physiology. Here, we utilize …

Aging and immunity are inextricably linked and many genes that extend life span also
enhance immunoresistance. However, it remains unclear whether longevity‐enhancing …

The genome of Caenorhabditis elegans encodes 284 nuclear hormone receptor, which
perform diverse functions in development and physiology. One of the best characterized of …