The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

Electrical signals generated by minute currents of ions moving across cell membranes are
central to all rapid processes in biology. Initiation and propagation of electrical signals …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …

In this review, we summarize our knowledge about mitochondrial potassium channels, with
a special focus on unanswered questions in this field. The following potassium channels …

Specific macromolecular transport systems, ion channels and pumps, provide the pathways
to facilitate and control the passage of ions across the lipid membrane. Ion channels provide …

Voltage-gated sodium (Na V) channels initiate and propagate action potentials in excitable
tissues to mediate key physiological processes including heart contraction and nervous …

Voltage‐gated sodium channels are essential for electrical signalling across cell
membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the …

Voltage-gated Na+ channels play an essential role in electrical signaling in the nervous
system and are key pharmacological targets for a range of disorders. The recent solution of …