The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …

The aim of systems biology is to describe and understand biology at a global scale where
biological functions are recognised as a result of complex mechanisms that happen at …

In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …

The functional integrity of the intestinal epithelial barrier relies on tight coordination of cell
proliferation and migration, with failure to regulate these processes resulting in disease. It is …

In this introductory article, we survey the contents of this Theme Issue. This Theme Issue
deals with a fertile region of hybrid dynamical systems that are characterized by the …

Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …

Making decisions on how best to treat cancer patients requires the integration of different
data sets, including genomic profiles, tumour histopathology, radiological images, proteomic …

Over the last 30 years, numerous research groups have attempted to provide mathematical
descriptions of the skin wound healing process. The development of theoretical models of …