Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in
the drug discovery and development of anticancer agents. Despite having numerous …

Colorectal cancer (CRC) is a globally prevalent malignancy with a high potential for
metastasis. Existing cancer treatments have limitations, including drug resistance and …

Onosma species (Boraginaceae) are well known as medicinal plants due to their wide range
of pharmaceutical potential. The present study aims to investigate the anticancer (in vitro) …

Cancer progression and metastases are the leading causes of poor outcomes in patients
with colon cancer. Colon cancer metastasis is a multigene, multistep, multistage complex …

Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

Shikonin is one of the major bioactive components of Lithospermum erythrorhizon. It has a
good killing effect in a variety of tumor cells. Its antitumor effect involves multiple targets and …

Abstract Zinc oxide nanoparticles (ZnO NPs) have exhibited excellent anti‐tumor properties;
the present study aimed to elucidate the underlying mechanism of ZnO NPs induced …

Shikonin, derived from the herb Lithospermum erythrorhizon (Purple Cromwell), is
extensively utilized in traditional Chinese medicine as an anti-inflammatory agent; however …

diCQA has been shown to have anti-tumor effect by decreasing cancer cell growth.
However, the molecular mechanism by which 3, 5-diCQA impacts colorectal cancer (CRC) …

Colorectal cancer (CRC) is a prevalent malignancy with high mortality rates and poor
prognosis. Shikonin (SHK) has demonstrated extensive anti-tumor activity across various …