The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries
and regions of the world, and is undoubtedly the defining public-health crisis of our time …

Since breaking onto the scene 26 years ago, HIV has proven an indefatigable foe. Over 60
million people have been infected with this retrovirus, and 25 million have already died of …

CCR5, a coreceptor for HIV-1 entry, is a major target for drug and genetic intervention
against HIV-1. Genetic intervention strategies have knocked down CCR5 expression levels …

Conclusion: Given the ever-growing roles and importance of exosomes in both host and
pathogen response, this review will address the impact role of exosome biogenesis and …

A variety of molecules in human blood have been implicated in the inhibition of HIV-1.
However, it remained elusive which circulating natural compounds are most effective in …

Intrarectal infection between men who have sex with men represents a predominant form of
human immunodeficiency virus (HIV) transmission in developed countries. Currently there …

A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for
proteasomal degradation. This function has been proposed to occur by a mechanism that is …

Viruses have evolved strategies to protect infected cells from apoptotic clearance. We
present evidence that HIV-1 possesses a mechanism to protect infected macrophages from …

Kidney disease is an important complication of HIV, particularly in minority populations. We
describe the burden of chronic kidney disease among 1239 adults followed at an urban …

Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to
human immunodeficiency virus type 1 (HIV-1) and a subset of related simian …