COVID-19 in relation to hyperglycemia and diabetes mellitus

HM Al-Kuraishy, AI Al-Gareeb, M Alblihed… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19), triggered by the severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2), may lead to extrapulmonary manifestations like diabetes …

Obesity, estrogens and adipose tissue dysfunction–implications for pulmonary arterial hypertension

KM Mair, R Gaw, MR MacLean - Pulmonary circulation, 2020 - journals.sagepub.com
Obesity is a prevalent global public health issue characterized by excess body fat. Adipose
tissue is now recognized as an important endocrine organ releasing an abundance of …

The role of adipocytes and adipocyte‐like cells in the severity of COVID‐19 infections

IL Kruglikov, PE Scherer - Obesity, 2020 - Wiley Online Library
Coronavirus disease‐2019 (COVID‐19), caused by the highly pathogenic severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), demonstrates high morbidity and …

PPARγ and TGFβ—major regulators of metabolism, inflammation, and fibrosis in the lungs and kidneys

G Kökény, L Calvier, G Hansmann - International journal of molecular …, 2021 - mdpi.com
Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …

EGR1 transcription factor is a multifaceted regulator of matrix production in tendons and other connective tissues

E Havis, D Duprez - International journal of molecular sciences, 2020 - mdpi.com
Although the transcription factor EGR1 is known as NGF1-A, TIS8, Krox24, zif/268, and
ZENK, it still has many fewer names than biological functions. A broad range of signals …

Reelin through the years: From brain development to inflammation

A Alexander, J Herz, L Calvier - Cell reports, 2023 - cell.com
Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Interplay of low-density lipoprotein receptors, LRPs, and lipoproteins in pulmonary hypertension

L Calvier, J Herz, G Hansmann - Basic to Translational Science, 2022 - jacc.org
The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

Crosstalk between the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor gamma (PPARγ) as a key factor in the metabolism of silver …

B Skóra, P Matuszewska, M Masicz, K Sikora… - Toxicology and Applied …, 2023 - Elsevier
The potential usefulness of silver nanoparticles (AgNPs) in anticancer therapy has been
postulated for many years. However, little is known to date about the exact impact of such …

Coronavirus disease 2019 (COVID‐19) and obesity. Impact of obesity and its main comorbidities in the evolution of the disease

IM Cornejo‐Pareja, AM Gómez‐Pérez… - European Eating …, 2020 - Wiley Online Library
The COVID‐19 pandemic is posing a great challenge worldwide. Its rapid progression has
caused thousands of deaths worldwide. Although multiple aspects remain to be clarified …

[HTML][HTML] Fatty acid nitroalkene reversal of established lung fibrosis

A Koudelka, V Cechova, M Rojas, N Mitash… - Redox Biology, 2022 - Elsevier
Tissue fibrosis occurs in response to dysregulated metabolism, pro-inflammatory signaling
and tissue repair reactions. For example, lungs exposed to environmental toxins, cancer …