[HTML][HTML] Emerging role of dipeptidyl peptidase-4 in autoimmune disease

J Huang, X Liu, Y Wei, X Li, S Gao, L Dong… - Frontiers in …, 2022 - frontiersin.org
Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an
ubiquitously expressed protease presented as either a membrane-bound or soluble form …

[HTML][HTML] A novel pathway of flavonoids protecting against inflammatory bowel disease: modulating enteroendocrine system

M Li, B Weigmann - Metabolites, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a comprehensive term for chronic or relapsing
inflammatory diseases occurring in the intestinal tract, generally including Crohn's disease …

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

I Vukelić, D Detel, LB Pučar, I Potočnjak… - Food and Chemical …, 2018 - Elsevier
Chlorogenic acid (ChA) exhibits a multitude of positive health effects, however, the signaling
mechanisms by which ChA could influence the inflammatory response in experimental …

[HTML][HTML] Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model

S Ding, Y Ma, G Liu, W Yan, H Jiang, J Fang - Frontiers in Physiology, 2019 - frontiersin.org
The aim of this study was to examine the effects of Lactobacillus brevis on the microbial
community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR …

[HTML][HTML] Role of glucagon-like peptides in inflammatory bowel diseases—current knowledge and future perspectives

H Zatorski, M Sałaga, J Fichna - Naunyn-Schmiedeberg's archives of …, 2019 - Springer
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are chronic, relapsing, intestinal inflammatory disorders with complex and yet …

[HTML][HTML] Role of incretin axis in inflammatory bowel disease

L Duan, X Rao, Z Braunstein, AC Toomey… - Frontiers in …, 2017 - frontiersin.org
The inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative
colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract and involve a …

Crosstalk between incretin hormones, Th17 and Treg cells in inflammatory diseases

EM da Silva, VY Yariwake, RW Alves, DR de Araujo… - Peptides, 2022 - Elsevier
Intestinal epithelial cells constantly crosstalk with the gut microbiota and immune cells of the
gut lamina propria. Enteroendocrine cells, secrete hormones, such as incretin hormones …

CD26 in autoimmune diseases: the other side of “moonlight protein”

Y Zhao - International Immunopharmacology, 2019 - Elsevier
Abstract Dipeptidyl peptidase 4 (DPP-4) is a serine protease, which has enzymatic activity to
selectively clean the N-terminal dipeptide of peptides and proteins with proline or alanine in …

[HTML][HTML] Empagliflozin attenuates intestinal inflammation through suppression of nitric oxide synthesis and myeloperoxidase activity in in vitro and in vivo models of …

A Makaro, M Świerczyński, K Pokora, B Sarniak… - …, 2024 - Springer
Inflammatory bowel diseases (IBD) are characterized by chronic and relapsing inflammation
affecting the gastrointestinal (GI) tract. The incidence and prevalence of IBD are relatively …

Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors

K Rahim, M Shan, I Ul Haq, MN Nawaz… - Journal of …, 2024 - Taylor & Francis
Abstract DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player
in soluble and membrane-bound forms. Its heightened expression has been intimately …