Abdominal aortic aneurysm: update on pathogenesis and medical treatments
J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …
Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …
Monocytes and macrophages in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …
Understanding the pathogenesis of abdominal aortic aneurysms
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma
M Xiao, J Zhang, W Chen, W Chen - Journal of Experimental & Clinical …, 2018 - Springer
Background Treatment strategies targeting tumor-associated macrophages (TAMs) have
been proposed in cancer areas. The functional alterations of macrophages in the …
been proposed in cancer areas. The functional alterations of macrophages in the …
Translational relevance and recent advances of animal models of abdominal aortic aneurysm
J Sénémaud, G Caligiuri, H Etienne… - … , and vascular biology, 2017 - Am Heart Assoc
Human abdominal aortic aneurysm (AAA) pathophysiology is not yet completely understood.
In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth …
In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth …
[HTML][HTML] Emerging functions of thrombospondin-1 in immunity
S Kaur, DD Roberts - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …
interacting with components of the extracellular matrix and with several cell surface …
Extracellular matrix dynamics in vascular remodeling
Z Ma, C Mao, Y Jia, Y Fu… - American Journal of …, 2020 - journals.physiology.org
Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …
pathophysiological alterations that are closely related to aging and vascular diseases …
Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm—brief report
Objective: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease
characterized by smooth muscle cell depletion, ECM (extracellular matrix) degradation, and …
characterized by smooth muscle cell depletion, ECM (extracellular matrix) degradation, and …
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary
pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β …
pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β …