Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …

There have been extensive developments on cellular and molecular mechanisms of
immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ …

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

Abstract Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …

Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of
susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ …

The role of the immune system in anti-tumor immunity cannot be overstated, as it holds the
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …

Background Natural killer (NK) cells are an emerging new tool for cancer immunotherapy.
To develop NK cell therapeutics from peripheral blood mononuclear cells (PBMCs) of …

The tumor microenvironment (TME) is jointly constructed by a variety of cell types, including
tumor cells, immune cells, fibroblasts, and epithelial cells, among others. The cells within the …