Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as
having few associated serious adverse reactions. It was registered in about 20 countries …

Gout is a major health problem in the United States; it affects 8.3 million people, which is
approximately 4% of the adult population. Gout is most often diagnosed and managed in …

Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …

Background Allopurinol, a xanthine oxidase inhibitor, is considered one of the most effective
urate‐lowering drugs and is frequently used in the treatment of chronic gout. Objectives To …

Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs)
expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of …

Gout is a common form of arthritis. It is associated with a number of comorbidities, including
hypertension, cardiovascular disease, renal impairment, diabetes, obesity, hyperlipidaemia …

Uricosuric medications for chronic gout - Kydd, ASR - 2014 | Cochrane Library Skip to Content
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Aims The primary aim of this research was to predict the allopurinol maintenance doses
required to achieve the target plasma urate of≤ 0.36 mmol l− 1. Methods A population …

CALHM1 was recently demonstrated to be a voltage‐gated ATP‐permeable ion channel
and to serve as a bona fide conduit for ATP release from sweet‐, umami‐, and bitter‐sensing …

Uricosuric drugs: the once and future therapy for hyperurice... : Current Opinion in
Rheumatology Uricosuric drugs: the once and future therapy for hyperuricemia? : Current …