As an essential nutrient, manganese is required for the regulation of numerous cellular
processes, including cell growth, neuronal health, immune cell function, and antioxidant …

Manganese (Mn) is an essential trace element for humans, but long‐term environmental or
occupational exposures can lead to numerous health problems. Although many studies …

Manganese (Mn) exposure has evolved from acute, high-level exposure causing
manganism to low, chronic lifetime exposure. In this latter scenario, the target areas extend …

Background Hypermanganesemia with dystonia 1 and 2 (HMNDYT1 and 2) are rare,
inherited disorders of manganese transport. Objectives We aimed to describe clinical …

Background A genetic variant in the manganese transporter SLC30A10 (rs188273166, p.
Thr95Ile) was associated with increased plasma alanine transaminase (ALT) in a recent …

Zinc is an essential trace mineral. Dietary zinc deficiency results in stunted growth, skin
lesions, hypogonadism and frequent infections in humans. Mice genetically lacking Slc30a7 …

Background: Manganese associated neurotoxicity and neurodegeneration is quite rare yet
established neurological disorder. This neurotoxic element has predilection for depositing in …

Zinc transporters take up/release zinc ions (Zn2+) across biological membranes and
maintain intracellular and intra-organellar Zn2+ homeostasis. Since this process requires a …

Importance: Hypermanganesemia with dystonia type 2 is a rare autosomal recessive
neurodegenerative disorder characterized by the loss of previously acquired milestones …

We present a rare case of erythrocytosis due to a homozygous SLC30A10 mutation,
causative of Hypermanganesemia with Dystonia, Polycythemia, and Cirrhosis (HMDPC) …