Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the
blood and have major roles in hemostasis, thrombosis, inflammation, and vascular biology …

Potential applications of stem cells in medicine range from their inclusion in disease
modeling and drug discovery to cell transplantation and regenerative therapies. However …

Megakaryocytopoiesis and thrombocytopoiesis result from the interactions between
hematopoietic progenitor cells, humoral factors, and marrow stromal cells derived from …

MicroRNAs (miRNAs) have attracted attention because of their key regulatory functions in
many biological events, including differentiation and tumorigenesis. Recent studies have …

In the present investigation, we generated platelets (PLTs) from cord blood (CB) CD34+
cells using a three‐phase culture system. We first cultured 500 CB CD34+ cells on …

The late stages of megakaryocytopoiesis, consisting of the terminal processes of
cytoplasmic maturation and platelet shedding, remain poorly understood. A simple liquid …

The exciting and extraordinary capabilities of stem cells to proliferate and differentiate into
numerous cell types not only offers promises for changing how diseases are treated but may …

▪ Abstract Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, is an
enabling technology with many potential applications in bone-marrow transplantation …

Hematopoietic stem cells for transplantation | Nature Immunology Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Megakaryocytes (Mks) mature adjacent to bone marrow (BM) sinus walls and subsequently
release platelets within the sinusoidal space or in lung capillaries. As the sites for platelet …