The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Energy demand of neurons in brain that is covered by glucose supply from the blood is
ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of
obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in …

Abstract Purpose of Review Metformin has multiple benefits for health beyond its anti-
hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that …

Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has
been reported to decrease body weight, although the mechanism remains unclear. Here we …

Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …